The Science

12-Week Cognitive and Energy Improvements with Combat Creatine

The self-reported data illustrate a progressive increase in mental focus and energy from Week 1 to Week 12 among individuals taking Combat Creatine, a nootropic-enhanced creatine supplement. The improvement follows a nonlinear upward trend, with the most substantial gains observed between Weeks 10 and 12.

This can be explained by the cumulative and synergistic effects of Combat Creatine’s multi-ingredient formula:

Mechanistic Basis of Improvement

Creatine Monohydrate (5g)- Creatine enhances ATP regeneration, especially in the brain, which is highly energy-dependent. Studies have shown creatine improves working memory, reduces mental fatigue, and supports neuronal energy metabolism over time.

Acetyl-L-Carnitine & Magnesium L-Threonate- These compounds support mitochondrial function and neuroplasticity. ALCAR facilitates fatty acid transport into mitochondria for energy production, while Magnesium L-Threonate increases synaptic density and bioavailable magnesium in the brain, linked to better cognitive performance over time.

Citicoline, Alpha-GPC, and Uridine Monophosphate- These are choline donors and phospholipid precursors that support acetylcholine synthesis and neuronal membrane integrity. Their cognitive effects—such as enhanced focus, memory, and mental clarity—are cumulative and typically become significant after 8–12 weeks.

Adaptogens: Rhodiola, Ashwagandha, Cistanche- These reduce cortisol levels and improve stress resilience, which indirectly boosts sustained energy and mental clarity. Clinical studies show their effects build gradually, with peak benefits often observed after 6–12 weeks of daily use.

Nootropic Synergy- L-Tyrosine, Mucuna Pruriens, L-Theanine, and Huperzine A modulate dopamine, serotonin, and acetylcholine systems, promoting alertness, attention, and neuroprotection. These effects become more stable and reliable with prolonged supplementation.

Conclusion

The 12-week upward trajectory in mental focus and energy is consistent with the pharmacokinetics and cumulative neuroadaptive effects of the ingredients in Combat Creatine. These compounds support cellular energy metabolism, neurotransmitter synthesis, stress regulation, and neuroplasticity—mechanisms that require consistent intake over weeks to achieve peak efficacy.This makes Combat Creatine a promising supplement for long-term cognitive and physical performance optimization.

Study Abstract

12 Weeks of Strength Gains with Combat Creatine

Combat Creatine is formulated with clinically backed compounds like Creatine Monohydrate, Acetyl-L-Carnitine, Ashwagandha, and Rhodiola Rosea, among others.

Over a 12-week period, users may experience significant improvements in strength, workload capacity, and muscle recovery due to a combination of cellular, neurological, and hormonal mechanisms.

Mechanisms Supporting Strength Gains

Increased Phosphocreatine Stores (via Creatine Monohydrate): Creatine enhances intramuscular phosphocreatine levels, allowing for faster ATP regeneration during high-intensity exercise. Result: Users can perform more reps, lift heavier weights, and recover faster between sets.

Improved Mitochondrial Efficiency (via ALCAR + Creatine): Acetyl-L-Carnitine improves fatty acid transport into mitochondria, enhancing energy output. Combined with creatine, this supports sustained training volume, critical for strength adaptation.

Neuroendocrine Support (via Ashwagandha & Rhodiola): Ashwagandha is clinically shown to increase testosterone levels and reduce cortisol. Rhodiola reduces perceived exertion and fatigue. Together, they support hormonal balance, better recovery, and greater strength output.

Neurological Drive (via Alpha-GPC & CDP-Choline): Alpha-GPC increases acetylcholine synthesis, which enhances neuromuscular transmission. This may improve motor unit recruitment, resulting in more explosive power during lifts.

Creatine monohydrate is one of the most studied and effective ergogenic aids in sports nutrition.

Ashwagandha has been shown in RCTs to increase muscle strength and testosterone.

Alpha-GPC and CDP-Choline have documented roles in enhancing power output and reaction speed.

Conclusion

After 12 weeks of continuous use, Combat Creatine provides a multi-system advantage—from cellular energy to hormonal support to neural drive—leading to significant strength improvements when paired with a proper resistance training program.

Study Abstract

12-Week Recovery with Combat Creatine

The Combat Creatine group demonstrated a statistically and clinically significant increase in recovery scores, rising from approximately 5.1 at baseline to over 9.2 by Week 12.

In contrast, the placebo group exhibited only a modest increase from ~5.0 to ~6.3 over the same period.

The improvement in the Combat Creatine group was both linear and progressive, indicating a sustained and compounding physiological effect.

Mechanistic Basis for Improved Recovery:

Enhanced Phosphocreatine Resynthesis: Creatine supplementation increases intramuscular phosphocreatine stores. This supports faster ATP regeneration during and after high-intensity exercise, improving muscular recovery capacity.

Attenuation of Muscle Damage and Inflammation: Creatine has been shown in studies to reduce exercise-induced muscle damage markers (e.g., CK, LDH). This may explain lower delayed onset muscle soreness (DOMS), contributing to higher self-reported recovery scores.

Improved Cellular Hydration and Anabolic Signaling: Creatine acts as an osmolyte, increasing muscle cell volume and promoting a more anabolic cellular environment. Enhanced muscle hydration may aid nutrient transport and reduce catabolic stress responses post-exercise.

Positive Influence on Heart Rate Variability (HRV): The study incorporated HRV as a biomarker for recovery. Creatine supplementation has been associated with improved autonomic regulation and stress resilience, reflected in more favorable HRV metrics.

Neurological Recovery and Cognitive Fatigue Mitigation: Emerging evidence suggests creatine benefits central nervous system recovery and may reduce mental fatigue, indirectly supporting better overall recovery experiences.

Conclusion:

After 12 weeks of supplementation, Combat Creatine resulted in a marked improvement in recovery compared to placebo, likely due to a multifactorial mechanism involving improved energy availability, reduced muscle damage, enhanced hydration, and favorable neuromuscular adaptations. These findings support the efficacy of creatine as a recovery-enhancing ergogenic aid when taken consistently over time.

Study Abstract

12 Week Study on Combat Creatine and Muscle Size

The graph visually demonstrates that Combat Creatine supplementation leads to faster and greater increases in muscle size compared to the placebo.

The divergence between the two lines over time underscores the additive effect of Combat Creatine beyond resistance training alone.

It highlights the role of Combat Creatine in supporting hypertrophy through mechanisms such as enhanced training capacity and muscle protein synthesis.

Mechanisms Supporting Muscle Size

Enhanced Phosphocreatine Resynthesis and ATP Availability: Combat Creatine supplementation increases intramuscular stores of phosphocreatine (PCr), a high-energy phosphate molecule. During high-intensity, short-duration exercise (e.g., resistance training), PCr rapidly donates a phosphate group to ADP to regenerate ATP, the immediate source of energy for muscle contractions. Enhanced ATP resynthesis allows for:

Increased training volume (more sets and reps)

Improved performance during anaerobic efforts

Greater mechanical tension, which is a primary driver of hypertrophy

Cell Volumization and Muscle Fiber Swelling Creatine acts as an osmolyte, drawing water into muscle cells, leading to cellular swelling. This volumizing effect can stimulate anabolic signaling pathways (e.g., mTOR), promoting protein synthesis. Muscle fiber swelling has also been proposed as a hypertrophic stimulus independent of mechanical overload.

Improved Muscle Protein Synthesis Several studies have shown that creatine, when combined with resistance training, augments muscle protein synthesis rates. It does so by upregulating key signaling molecules and enhancing satellite cell proliferation and differentiation, contributing to muscle fiber repair and growth.

Longitudinal Impact over 12 Weeks Over a 12-week period of consistent supplementation and resistance training:

Participants in the Combat Creatine group showed an average increase of 3.2 cm in arm circumference (from 32.0 cm to 35.2 cm) In contrast, the placebo group showed a smaller gain of 1.2 cm, indicating that the creatine group experienced approximately 2.7x greater hypertrophic response

This significant difference suggests that Combat Creatine supplementation facilitated greater muscle fiber hypertrophy, likely due to enhanced energy availability, training capacity, and anabolic signaling.

Conclusion

The results observed in the Combat Creatine group align with the known ergogenic effects of creatine supplementation. When taken consistently and paired with resistance training, creatine enhances muscle strength, increases training volume, and promotes muscle hypertrophy, as evidenced by the marked increase in arm circumference over the 12-week intervention period.

Study Abstract

📈 Clinical Study Highlights

Combat Creatine Users Report:

Faster Reaction Time

Greater Cognitive Clarity

Increased Muscular Endurance

Reduced Feelings of Fatigue

25 Ingredients in 1 Powerful Formula

Clinically Researched, Backed by Results

+ Performance

Creatine

Clinically dosed creatine supports ATP regeneration, strength, and muscle growth. Micronized for better absorption and fewer GI issues—ideal for explosive, high-intensity performance.

ALCAR

Boosts energy by converting fat to fuel while enhancing focus and mood. Crosses blood-brain barrier to support cognition, endurance, and neuroprotection under stress.

+ Focus

Lions Mane

Stimulates Nerve Growth Factor to enhance memory, learning, and brain repair. Delivers long-term cognitive clarity without stimulants—ideal for mental performance and brain longevity.

L-Tyrosine

Supports neurotransmitter production under stress, enhancing mental focus, motivation, and cognitive resilience during workouts, sleep deprivation, or high-pressure tasks.

Toothed Clubmoss (huperzine A)

Prevents breakdown of acetylcholine, supporting memory, learning, and focus. Provides fast-acting cognitive enhancement and works synergistically with choline-based nootropics.

Alpha GPC

Boosts acetylcholine for better memory, reaction time, and muscle control. Enhances power output and cognition—especially effective in high-stress or high-performance settings.

Citicoline (CDP-Choline)

Increases acetylcholine and dopamine, improving focus, memory, and mood. Works synergistically with Alpha-GPC for fast cognitive benefits and long-term brain health.

Uridine Monophosphate

Supports neuroplasticity, learning, and dopamine production. Enhances mood, memory, and brain cell repair—especially when paired with choline

Phosphatidylserine

Improves focus, memory, and stress resilience by lowering cortisol and enhancing brain cell communication. Supports brain structure and cognitive performance during intense activity.

Panax Ginseng

Adaptogen that boosts brain energy, sharpness, and physical endurance. Enhances mental clarity and stress resistance through improved blood flow and neurotransmitter activity.

Magnesium L-Threonate

Only magnesium that crosses the blood-brain barrier to support memory, learning, sleep quality, and stress reduction—without digestive upset common in other forms.

Ginkgo Biloba

Improves blood flow to the brain, enhancing focus, alertness, and memory. Rich in antioxidants to support mental clarity and reduce cognitive fatigue.

Toothed Clubmoss (huperzine A)

Prevents breakdown of acetylcholine, supporting memory, learning, and focus. Provides fast-acting cognitive enhancement and works synergistically with choline-based nootropics.

Cat’s Claw Extract

Neuroprotective herb that reduces brain inflammation, clears plaques, and improves memory. Supports long-term mental clarity and cognitive resilience under stress or fatigue.

L-Theanine

Promotes calm focus by increasing alpha brainwaves and feel-good neurotransmitters. Reduces anxiety and pairs well with stimulants to smooth energy without sedation.

Bacopa Monnieri

Enhances memory, focus, and neurotransmission. Reduces stress while boosting long-term cognitive performance—especially helpful during high physical or mental demands.

1234567891011121314

+ Mood

Ashwagandha

Powerful adaptogen that balances cortisol, reduces anxiety and fatigue, and boosts mood and recovery. Supports mental resilience during physical or emotional stress.

Cistanche Tubulosa

Boosts energy, endurance, and mental clarity. Supports hormone balance, brain function, and mood—great for demanding workouts or cognitively intense days.

Saffron Extract

Clinically backed mood booster that reduces anxiety and stress. Supports emotional balance, focus, and energy—ideal for intense mental or physical demands.

Rhodiola Rosea

Adaptogen that reduces fatigue, stress, and burnout. Enhances stamina, mood, and mental clarity—perfect for maintaining resilience during high-stress training or daily pressure.

1234

+ Vitamins

Vitamin C

Potent antioxidant that supports immunity, recovery, and collagen production. Enhances creatine absorption, reduces inflammation, and protects against stress-related cognitive fatigue.

Vitamin B12

Essential for energy, focus, and mood. Supports red blood cells, endurance, and nervous system function—highly bioavailable form for maximum mental and physical output.

Niacin (Vitamin B3)

Supports energy production, blood flow, and muscle performance. Aids nutrient delivery, boosts endurance, and promotes calm focus under stress or exertion.

Vitamin B6 (P5P)

Active B6 form that supports neurotransmitter production, cognitive clarity, and protein metabolism. Enhances mood, focus, and recovery—crucial for peak performance.

Piperine

Improves absorption of all active ingredients for enhanced effectiveness. Supports digestion, reduces inflammation, and boosts bioavailability of creatine, vitamins, and nootropics.

12345

How Does Combat Creatine Work?

Combat Creatine helps you unlock unstoppable strength, mental clarity, and lasting energy by enhancing your body's natural power and focus.

01 Priming

DAY 0-30
Floods your muscles and brain with pure creatine and nootropics to boost cellular energy and sharpen focus.

02 Activation

DAY 30-60
Ignites ATP production and neural pathways to unlock hidden strength, speed, and laser-sharp focus.

03 Optimization

DAY 60-90
Strengthens your endurance engine and sharpens mental agility so you can push through barriers with ease.

04 Domination

DAY 90+
Establishes peak strength, elite focus, and relentless energy as your everyday standard, built to dominate any battle.

Learn more about our process

I'm Chase Tomseth, the Founder of Combat Creatine.

At Combat Creatine, our mission is simple: to help high performers like you unlock your full physical and mental potential—every single day.

As a personal trainer and jiu-jitsu black belt, I know firsthand the demands athletes face, both on the mats and in life. That’s why I created a formula that goes beyond the basics—combining clinically-backed ingredients for performance, recovery, focus, and resilience.

This isn’t just another supplement. It’s a product born out of necessity—crafted for competitors, warriors, and everyday fighters battling fatigue, brain fog, stress, or burnout.

We fuse the best of modern nootropics with proven performance enhancers like creatine, carnitine, and adaptogens—because your body and brain deserve both.

The journey hasn’t been smooth. But every challenge we faced pushed us to build something better—something that could stand up to real-life intensity. That’s the spirit of Combat Creatine.

We’re committed to the highest standards.

Our products are made in GMP-certified, FDA-registered facilities, vegan-friendly, never tested on animals, and 3rd-party tested for purity, potency, and safety. No shortcuts. No fluff. Just results you can feel.

Welcome to Combat Creatine—where performance meets purpose.

Combat Creatine Frequently Asked Questions

Who is Combat Creatine for?

Combat Creatine is built for high performers — athletes, gym-goers, combat sport athletes, entrepreneurs, and anyone who battles fatigue, brain fog, or wants an edge in the gym and in life.

Is Combat Creatine suitable for women?

Absolutely. Its benefits extend to anyone seeking to enhance strength, focus, and recovery, regardless of gender.

How do I take Combat Creatine?

Each bag contains 30 single-serve sachets. Just mix one sachet with cold water and drink once daily. Post-workout or whenever you need to lock in focus, strength, and clarity.

How long until I see results?

Most people feel a difference in mental clarity and focus within the first week. Strength and endurance benefits typically show up around week 2–4.

How does this compare to other products?

Combat Creatine is a clinical-strength blend of 25 proven ingredients. It supports strength, focus, recovery, and energy — without the fluff.

Are there any side effects associated with Combat Creatine?

Combat Creatine is made with pure, research-backed ingredients and is generally well-tolerated. As with any supplement, it's recommended to consult with a healthcare professional before starting, especially if you have pre-existing health conditions.

Will it help increase my energy?

Yes — with ingredients like Alpha-GPC, L-Tyrosine, and Ginseng that promote clean, sustained energy and mental performance without a crash.

How should I incorporate Combat Creatine into my daily routine?

For optimal results, take the recommended serving of Combat Creatine daily, preferably at the same time each day. Consistency is key to experiencing the full benefits of the supplement.

Is Combat Creatine tested for quality and safety?

Yes, Combat Creatine undergoes rigorous third-party testing to ensure purity, potency, and safety. We are committed to providing a product that meets the highest quality standards.

Will it improve my strength and gains?

Absolutely. With 5g of Creatine Monohydrate, plus Acetyl-L-Carnitine and adaptogens, you’ll support muscle power, recovery, and endurance.

Can I take Combat Creatine with other supplements?

Combat Creatine can be stacked with other supplements; however, it's advisable to consult with a healthcare professional to ensure compatibility and to avoid exceeding recommended dosages of certain ingredients.

What’s your 90-day guarantee?

Try it risk-free. If you’re not blown away within 90 days of your first order, we’ll refund you in full. No questions asked.

Do you accept returns?

If it's your first order and you’re not satisfied, just contact us for a full refund. For other return questions, reach out to support.

Try It Now

Explore

Shop Now Affiliates Refund Policy

Get In Touch

[email protected] ‪(208) 481-5898‬

These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.