Ginkgo Biloba: Benefits, Risks, and Side Effects

Ginkgo Biloba: Benefits, Risks, and Side Effects

May 04, 2025

Ginkgo Biloba: Nature’s Brain Booster with Powerful Benefits

Ginkgo biloba, often misspelled as gingko biloba, is one of the most researched and widely used herbal supplements in the world.


Known for its brain-boosting properties and potential to support memory, focus, and overall mental clarity, the ginkgo tree has stood the test of time—literally.


As one of the oldest living tree species on Earth, the leaves and seeds of this plant have been used for thousands of years in traditional medicine.


This article explores everything you need to know about ginkgo biloba—from its proven effects to potential side effects, how to use it properly, and what the latest research says about its role in cognitive health, circulation, and more.


Whether you're curious about the effect of ginkgo biloba or want to understand the efficacy and safety of ginkgo, this guide has you covered with in-depth, research-backed insights.


Article Outline

1. What Is Ginkgo Biloba and Why Is It So Popular?

2. How Does Ginkgo Biloba Work in the Body?

3. What Are the Proven Benefits of Ginkgo Biloba?

4. Is Ginkgo Biloba Good for Memory and Cognitive Function?

5. Can Ginkgo Biloba Help with Depression or Anxiety?

6. How Effective Is Ginkgo Biloba for Dementia and Alzheimer’s?

7. What Is Ginkgo Biloba Extract EGB 761 and Why Is It Important?

8. Are There Any Side Effects or Risks from Taking Ginkgo Biloba?

9. How and When Should You Take Ginkgo Biloba?

10. What Does the Research Say About Ginkgo Biloba's Effectiveness?

Close up of green gingko leaf

1. What Is Ginkgo Biloba and Why Is It So Popular?

Ginkgo biloba is derived from the ginkgo tree, a living fossil that has existed for over 200 million years. The ginkgo leaf, in particular, is valued for its medicinal properties, often processed into ginkgo biloba extract for supplements.


The ginkgo plant has been used in traditional Chinese medicine for centuries.


Today, many people take ginkgo for its potential cognitive benefits, especially in aging populations. Ginkgo may help improve memory, slow cognitive decline, and support mental clarity.


Modern formulations often use a standardized ginkgo biloba extract, which ensures consistent doses of active compounds. The most commonly studied version is known as ginkgo biloba extract EGB 761®.


2. How Does Ginkgo Biloba Work in the Body?

The effect of ginkgo biloba is primarily due to its ability to improve blood flow, particularly to the brain and extremities. This is why many believe that ginkgo may help with issues like memory loss, poor circulation, and even sexual dysfunction.


Compounds found in ginkgo leaves contain antioxidants called flavonoids and terpenoids, which reduce oxidative stress in brain cells.


The extract of ginkgo biloba also acts as a vasodilator, meaning it helps expand blood vessels to increase circulation.


The chemical analysis of ginkgo biloba shows that these antioxidants may combat free radicals, which can damage cells and accelerate aging.


3. What Are the Proven Benefits of Ginkgo Biloba?

Studies show that ginkgo may support a range of health benefits, especially in brain health and blood circulation.


The effectiveness of ginkgo includes:

  • Enhancing cognitive performance and memory.
  • Reducing symptoms of anxiety.
  • Supporting eye and ear health due to improved blood flow.
  • Combating inflammation through antioxidant activity.


Some also use ginkgo as a natural way to alleviate antidepressant-induced sexual dysfunction, with one trial focusing on ginkgo biloba for antidepressant-induced sexual side effects showing promising results.


4. Is Ginkgo Biloba Good for Memory and Cognitive Function?

Many people take ginkgo biloba for cognitive impairment or to enhance focus and mental clarity.


The ginkgo evaluation of memory and similar trials, such as the placebo-controlled trial of ginkgo biloba, found that treatment with ginkgo biloba may modestly improve cognitive performance in older adults.


A meta-analysis of ginkgo biloba preparation found that long-term use can result in better cognitive function, particularly in individuals with mild cognitive impairments.


Interestingly, a trial of the ginkgo biloba extract revealed improved attention and processing speed in healthy adults as well.


5. Can Ginkgo Biloba Help with Depression or Anxiety?

The effects of ginkgo biloba leaf extend to mood regulation as well. Clinical observations and anecdotal evidence suggest that ginkgo may also support emotional well-being by enhancing blood circulation to the brain and reducing cortisol levels.


One study of ginkgo biloba suggested that combining coenzyme Q10 and ginkgo biloba might improve energy levels and mood in people with fatigue and depression.


Though more large-scale studies are needed, the effect of ginkgo biloba extract on mood seems to be promising—especially when used in combination with other therapies.


6. How Effective Is Ginkgo Biloba for Dementia and Alzheimer’s?

One of the most compelling uses of ginkgo biloba is in managing symptoms of Alzheimer’s disease and dementia. The efficacy of ginkgo biloba extract has been tested in multiple studies involving elderly patients.


In a placebo-controlled trial of the ginkgo, participants treated with ginkgo biloba extract showed modest improvements in cognitive scores. Similarly, research into ginkgo biloba extract in dementia has indicated that ginkgo may help treat symptoms such as confusion, memory loss, and lack of focus.


The biloba extract for the treatment of neurodegenerative disorders is especially common in Europe, where it's often prescribed as part of integrative care.


7. What Is Ginkgo Biloba Extract EGB 761 and Why Is It Important?

Ginkgo biloba extract EGB 761 is a patented, standardized formulation used in most scientific studies. This version of ginkgo biloba special extract EGB guarantees a consistent concentration of active compounds—mainly flavone glycosides and terpene lactones.


The efficacy and safety of ginkgo rely heavily on this specific extract. For instance, a trial of ginkgo biloba extract EGB761 confirmed cognitive and circulatory benefits without serious adverse effects.


When choosing a supplement, it's important to look for products containing biloba special extract EGB 761 or standardized ginkgo biloba extract to ensure you're getting the researched dosage and benefits.


8. Are There Any Side Effects or Risks from Taking Ginkgo Biloba?

While ginkgo biloba is generally safe for most people, it’s not without risks. Some users experience serious side effects, including headaches, dizziness, and digestive issues.


Ginkgo may increase the risk of bleeding, especially if taken with blood thinners like warfarin. In fact, studies on ginkgo biloba on warfarin dosage and ginkgo biloba with cilostazol suggest that interactions should be carefully monitored.


Avoid the ginkgo seed or ginkgo nut, especially raw or roasted ginkgo seeds, as they can be toxic.


The safety of ginkgo biloba extract is highest when used according to dosage guidelines, especially in standardized forms like ginkgo biloba extract EGB 761®.


9. How and When Should You Take Ginkgo Biloba?

Most experts recommend taking two doses of ginkgo biloba daily, ranging from 120 mg to 240 mg, ideally in standardised ginkgo biloba extract form.


The best time to take ginkgo is with meals to improve absorption and reduce stomach discomfort. Some studies on the daily formulation of ginkgo biloba suggest splitting the dose into morning and evening servings.


Avoid using more than the recommended doses of ginkgo biloba extract, and consult a doctor if you're on medication. Ginkgo biloba on the pharmacokinetics of some drugs shows potential interactions.


10. What Does the Research Say About Ginkgo Biloba's Effectiveness?

The efficacy of the ginkgo biloba extract continues to be the subject of research. Overall, studies support its role in enhancing memory, improving circulation, and reducing inflammation.


Interaction studies of ginkgo biloba also emphasize caution when combining with medications. However, in healthy individuals, ginkgo biloba in healthy populations seems to offer a safe cognitive boost.


Whether ginkgo is right for you depends on your goals. For some, it’s a nootropic; for others, it’s a circulation aid.


But most agree: ginkgo has a long history of effectiveness when used properly.


🔍 Key Takeaways: What to Remember About Ginkgo Biloba

  • 🌿 Ginkgo biloba is a powerful natural supplement derived from the ginkgo leaf with a long history in traditional medicine.
  • 🧠 Ginkgo may help improve memory, focus, and cognitive function, especially in older adults.
  • 💊 Look for standardised ginkgo biloba extract like EGB 761® for clinically supported results.
  • 🧪 The effect of ginkgo biloba extract includes enhanced blood flow, antioxidant activity, and neuroprotection.
  • 🩸 Be cautious when combining ginkgo biloba with blood thinners or medications—consult your healthcare provider.
  • ⏱️ Optimal results occur with consistent, daily use in proper dosages (typically 120–240 mg/day).
  • ⚠️ Avoid the ginkgo seed and ginkgo nut due to potential toxicity—stick to extracts from the ginkgo leaf.
  • 📚 Ongoing research supports the effectiveness of ginkgo, particularly in cognitive health and age-related decline.


Works Cited (MLA Format)

  • Mahadevan, S., and S. Park. “Multifaceted Therapeutic Benefits of Ginkgo biloba L.: Chemistry, Efficacy, Safety, and Uses.” Journal of Food Science, vol. 73, no. 1, 2008, pp. R14–R19.
  • Oken, Barry S., et al. “The Efficacy of Ginkgo Biloba on Cognitive Function in Alzheimer’s Disease.” Archives of Neurology, vol. 55, no. 11, 1998, pp. 1409–1415.
  • Birks, J., and J. Grimley Evans. “Ginkgo biloba for Cognitive Impairment and Dementia.” Cochrane Database of Systematic Reviews, no. 4, 2009.
  • Kleijnen, Jos, and Paul Knipschild. “Ginkgo Biloba for Cerebral Insufficiency.” British Journal of Clinical Pharmacology, vol. 34, no. 4, 1992, pp. 352–358.
  • Diamond, B. J., et al. “Ginkgo Biloba Extract: Mechanisms and Clinical Indications.” Archives of Physical Medicine and Rehabilitation, vol. 81, no. 5, 2000, pp. 668–678.