12-Week Cognitive and Energy Improvements with Combat Creatine: A Pilot Observational Study
Abstract
Background: Nootropic supplementation is increasingly investigated for its role in enhancing mental performance and subjective energy. Combat Creatine is a novel nootropic-enhanced creatine formulation hypothesized to improve both parameters over time.
Objective: To evaluate the effects of daily Combat Creatine supplementation on self-reported cognitive focus and perceived energy levels over a 12-week period in healthy adults.
Methods: In this prospective observational study, participants (n = 36) self-administered Combat Creatine daily. Weekly assessments of mental focus and energy were recorded using 10-point Likert scales.
Results: Focus scores increased from 4.1 ± 0.9 to 8.2 ± 0.7; energy scores from 4.3 ± 1.1 to 8.5 ± 0.6 over 12 weeks.
Conclusion: Combat Creatine may provide cumulative cognitive and energetic benefits over 12 weeks. Controlled trials are recommended.
Keywords: creatine, nootropics, cognitive enhancement, adaptogens, energy metabolism, supplementation
1. Introduction
Cognitive fatigue and attention deficits are common among high performers. Creatine has shown promise in brain ATP support. Combat Creatine combines creatine with nootropics, adaptogens, and mitochondrial agents. This study assesses cognitive and energy changes over 12 weeks.
2. Methods
2.1 Participants
36 healthy adults (21–43 years; 52% female) were recruited online. Exclusions: other nootropics, neuropsychiatric disorders, chronic illnesses.
2.2 Supplement Intervention Daily dose of Combat Creatine included:
- Creatine Monohydrate (5 g)
- Acetyl-L-Carnitine (ALCAR)
- Magnesium L-Threonate
- Citicoline, Alpha-GPC, Uridine Monophosphate
- Adaptogens: Rhodiola, Ashwagandha, Cistanche
- Nootropics: L-Tyrosine, Mucuna Pruriens, L-Theanine, Huperzine A
Compliance was monitored via digital check-ins.
2.3 Data Collection
Weekly self-assessments of focus and energy using 10-point Likert scales via secure web platform.
2.4 Statistical Analysis
Means ± SD were calculated. Regression analysis evaluated trends. Visualization via Python's Matplotlib and Seaborn.
3. Results
Subjective improvements in focus and energy were reported. Gains accelerated post-Week 6, peaking by Week 12.
Focus Scores (Mean ± SD): - Week 1: 4.1 ± 0.9
- Week 6: 5.8 ± 1.0
- Week 12: 8.2 ± 0.7
Energy Scores (Mean ± SD): - Week 1: 4.3 ± 1.1
- Week 6: 6.1 ± 0.8
- Week 12: 8.5 ± 0.6
Trend analysis suggested sigmoidal growth—supporting a cumulative, nonlinear response.
4. Discussion
Results support Combat Creatine’s ingredient synergy. Creatine enhances ATP, ALCAR and magnesium support mitochondria, and cholinergic agents (citicoline, Alpha-GPC) boost neurotransmission. Adaptogens aid stress modulation. Dopaminergic nootropics support sustained attention. The 10–12 week peak matches neuroadaptive timelines from prior studies.
5. Conclusion
Daily Combat Creatine use for 12 weeks may improve focus and energy. Findings are promising but require validation via randomized controlled trials.
Conflict of Interest Statement
The authors declare no conflicts of interest related to this study.
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